Prenzlauer Berg is a fashionable area north of Mitte. Interesting bars, bohemian cafés and kitsch boutiques dot its most frequented streets like Kastanienallee and Oderberger Straße. It doesn't have the edge that Kreuzberg has, but it's a great place to visit for its laid-back atmosphere.
To get a feel for the local area, head to the Mauerpark. This former border strip has a fleamarket on Sundays as well as spontaneous parties that last well into the night. The nearby Kulturbrauerei also offers frequent night time entertainment.
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