Prague has two train stations and one bus terminal.
From Praha hlavní nádraží, the main train station, you can take most of the regional and international routes. It’s connected to Metro line C and is a beautiful place to sit and read the paper.
If you’re heading north or west, or going to Dresden or Berlin you’ll have to make your way to Nádraží Holešovice via the metro line C.
For bus trips, go to Florenc, Prague’s main bus terminal, with regional and international departures. It is located in New Town, with a station on Metro lines B and C.
Lastly, the Czech Republic’s integrated regional transport system makes it very easy to plan daytrips from Prague. You can enter your departure point and destination in this integrated transport page.